The Investigation for New Discovery of Biomarkers
BioFIND was an observational clinical study designed to discover and verify biomarkers of Parkinson's disease (PD). The study was carried out at eight academic sites in the United States. Recruitment began in 2012 and closed in March of 2015. BioFIND collected clinical data and biospecimens, including blood and cerebrospinal fluid (CSF), in well-defined, moderately advanced PD subjects and healthy controls.
BioFIND followed standardized data acquisition protocols to ensure that tests and assessments conducted at multiple sites could be pooled. Data and samples acquired from study participants have been placed in a comprehensive Parkinson's database and biorepository and are available to the scientific community for research on novel PD biomarkers. The study aims to complement PPMI to produce the most comprehensive and long-ranging dataset available for biomarker discovery work throughout the PD community.
Only with collaborative efforts like BioFIND can we efficiently discover and verify biomarker candidates for PD. This study is sponsored by The Michael J. Fox Foundation for Parkinson's Research with support from the National Institute of Neurological Disorders and Stroke (NINDS).
Accessing Clinical Data and Biospecimens
Clinical data and biospecimens from BioFIND are available for request. Clinical data from BioFIND is hosted by the study Bioanalytics Core and applications for data access are reviewed in real time. More information about using the BioFIND data can be found on Accessing BioFIND Data.
BioFIND samples are available through the Biospecimen Resource Allocation Committee (BRAC), a collaborative resource access program with NINDS. For additional information on submitting requests to access BioFIND samples to the BRAC, including upcoming submission deadlines, please visit the NINDS PD-BRAC webpage. MJFF also funds promising projects that use BioFIND biospecimens. Submit a proposed budget using the proper template (Industry/For-Profit or Academic/Non-Profit) to email@example.com for review in parallel with the sample application submitted to NINDS.
The following research studies have been approved for sample use.
Available Biospecimens and Data*
|Clinical Data||Whole Blood Pellet||Plasma||Saliva||Urine||DNA||RNA||CSF|
*Numbers refer to submission from unique individuals. Typical submissions include: clinical data, 2 whole blood pellets, 12 ml plasma from whole blood, 8.5 ml whole blood for DNA extraction, 5-10 ml whole blood for RNA extraction, 10 ml cerebrospinal fluid.